肉毒桿菌製劑(CORETOX®、コアトックス)

CORETOX®是一種由肉毒桿菌產生的毒素(肉毒桿菌毒素)所製成的藥物。 它可以放鬆面部肌肉收縮進而改善皺紋。 當注射到咀嚼肌和小腿肌肉時,它可以用來縮小臉部和腿部的肌肉而達到瘦臉或瘦腿的效果。它還能減少汗液和鼻水分泌,進而改善腋窩、手腳的多汗症和花粉症的症狀。

肉毒桿菌注射的適應症和部位

肉毒桿菌注射的好處

  • 通過將其註射到您的臉上,您可以改善皺紋並改善鰓的張力,從而使您的臉變小。
  • 通過注射到腋窩、手掌和腳底來改善多汗症。
  • 通過注射到肩膀和小腿,改善肩膀僵硬,瘦腿。
  • 通過將其塗抹在鼻子上,它可以改善由花粉熱和鼻炎引起的流鼻涕。
  • 通過精細注入皮膚(Microbotox),它可以抑制皮脂。

我們的肉毒桿菌注射治療清單

有關治療的更多信息,請參閱以下頁面。

CORETOX特徴

我們的診所使用韓國公司medytox生產的CORETOX。以前,我們也處理日本艾爾建(Allergan)生產的Botox Vista,但我們不再這樣做,因為許多患者更喜歡CORETOX。

CORETOX

CORETOX是一種使用與Botox Vista相同的肉毒桿菌菌株的製劑,不含「人類血清白蛋白」和「動物來源的材料」。此外,通過去除「複合蛋白質」,減少了產生抗體(耐受性)的風險。此藥物在韓國有通過MFDS的承認,但在日本仍為未經厚生勞動省承認的藥物,因此在重度副作用出現時,無法使用日本國內的《藥品不良反應賠償制度》。

CORETOXBotox Vista
菌株Hall Hyper 菌株Hall Hyper 菌株
日本國內承認尚未已承認
人類血清白蛋白不含含有
動物來源的材料不含含有
複合蛋白質去除含有
Botox Vista和CORETOX的比較

如果您想了解更多關於美容醫學中使用的肉毒桿菌毒素製劑,請參閱以下文章。

用於肉毒桿菌注射的針頭

在我們的診所,我們使用最細的34G(直徑0.18毫米)顯微注射針。通過使用盡可能細的針頭,可以最大限度地減少疼痛和內出血。(我們對鰓使用33G針,對小腿使用30G針)

34G針粗細對比

無法接受CORETOX治療的對象

  1. 吞嚥困難、呼吸道疾病病史、有癲癇發作史、神經肌肉疾病或全身性重度肌無力者(如重症肌無力、Lambert-Eaton肌無力症候群、肌萎縮性脊髓側索硬化症等)。
  2. 懷孕、哺乳或有計畫懷孕的女性。
  3. 過去對肉毒桿菌治療或polysorbate(添加劑)有過敏史者。
  4. 有隅角閉鎖型青光眼或有其誘發因素(如有較窄隅角)的人。

CORETOX治療後的注意事項

  1. 避免摩擦、搓揉或按壓注射部位。
  2. 在注射後3小時內,請稍為刻意收縮治療部位的肌肉以產生些微皺紋,讓藥物能更平均擴散。
  3. 避免在治療後當天泡熱水澡、按摩、劇烈運動或飲酒。淋浴和化淡妝則不受限制。
  4. 女性請採取避孕措施,至少須持續到注射後第二次月經結束。 男性在注射後三個月內也須採取避孕措施
  5. 注射後一週內請不要捐血。

Common side effects for all treatments

  • Redness, swelling, pain, and heat at the injection site: Usually improves within a few hours to a day.
  • Internal bleeding: Very rare. It will disappear 1-2 weeks after treatment.
  • Headache: Occurs in 1~5% of patients. It is usually mild and will disappear in a few hours to few days.

Risks and precautions according to the treatment area

  • For all wrinkle treatments: Muscle movements may change and wrinkles may appear in other areas. It is important not to increase the dosage of CORETOX too much, as it will fully fulfill its anti-wrinkle effect if wrinkles are prevented from appearing with the facial expressions that are often performed on a daily basis.
  • Forehead and Frown lines (areas between eyebrows): Eyelid and eyebrow drooping (eyelids and eyebrows droop, eyes become heavier, and difficult to open the eyes) and eyebrow elevation (the outer eyebrows become lifted and there is a difference between the left and right eyebrows) may occur. Rarely, the width of double eyelid may narrow or change. Generally, all the symptoms will gradually improve in about 4 weeks. CORETOX injection to the areas between eyebrows may cause the muscles relax and the space widen. Forehead CORETOX treatment is not recommended for people in their 60s and older.
  • Crow’s feet (the corner of the eye): Brow elevation (lifting of the outer brow) and dry eyes have been reported in few patients.
  • Bunny lines: Although very rare, symptoms of double vision and running tears (watery eyes) have been reported.
  • Gummy smile: The philtrum (the indentation above the upper lip) may be elongated and the left and right corners of the mouth may become asymmetrical. When the left and right become asymmetrical, additional injections are made on the side that is elevated to correct the asymmetry.
  • Smile lines on the cheeks: Smiling may become unnatural or asymmetrical. Usually improves in 2~4 weeks.
  • Lips: Mouth squeezing movements and whistling may become difficult. It may be also difficult to pronounce “pa, pi, pu, pe, and po”.
  • Jaw: Mouth may become difficult to close, jaw may become elongated, and mouth may become distorted when smiling. The lower lip may become more easily caught between the teeth and the lower lip, or the lower lip may be bitten more easily.
  • Corner of mouth: Asymmetry of the left and right corners of the mouth may occur, and mouth may be distorted when smiling. Usually improves in 2~4 weeks.
  • Platysma muscle: Although very rare, the muscles in the center of the neck may relax and sag. Speech, swallowing, and movement disorders have been reported.
  • Masseters: This treatment is not recommended for people in their 40s or older, as the decrease size of masseter muscles can cause the skin to sag in their place and the cheeks to become hollow. Some muscles may bulge compensatory, and additional corrective CORETOX injections are used in these cases.
  • Shoulder and calf: Dull muscle pain, sagging, weakness, wobbliness, and tangling may occur, but will improve in 2~3 weeks. Decreased in strength may occur. Very rarely, neuropathy, numbness, and weakness may also occur.
  • Hay fever: Although the possibility of transient effects on the sense of smell cannot be ruled out theoretically, it is very rare in actual clinical practice.
  • Hyperhidrosis: Instead of a decrease in sweating in the treated area, there may be an increase in sweating from other areas (compensatory sweating). In the cases of hands or feet treatment, transient weakness, difficulty grasping objects, difficulty doing fine work, muscle pain, and numbness due to neuropathy may occur.

Severe side effects

Although very rare, the following side effects have been reported

  • Anaphylactic shock: Severe allergic symptoms (generalized rash, swelling of skin, lips, and tongue, dyspnea, palpitations, hypotension, disorientation, and convulsions).
  • Allergy to anesthesia or its ingredients or additives: Severe allergic symptoms (generalized rash, swelling of skin, lips, and tongue, dyspnea, palpitations, hypotension, disturbance of consciousness, convulsions) after using lidocaine tape or cream anesthesia.
  • Eye disorders: Corneal disorders due to difficulty in closing the eyes and dryness of the cornea.
  • Swallowing and breathing disorders: Symptoms such as dysphagia, change in voice quality, and dyspnea may occur after injections of 100 units or more into the neck muscles.
  • Seizures: seizures and recurrence of seizures may occur.

Other side effects

Other reported side effects include. There are specific side effects depending on the area of wrinkles treated, which will be explained in detail during the consultation.

Less than 1%Frequency unknown
Excessive muscle relaxationRabbit eyes, facial paralysis, localized hypotonia (cervical muscle weakness, drooping corners of the mouth, etc.)Ectropion, entropion, eyelid closure problems
EyeDiplopia, foggy eyesight, photophobia, eye fat, watery eyes, eye painEye irritation, strabismus, conjunctivitis, dry eyes, keratitis, corneal erosions, Impaired vision, eyelid edema
SkinRash, itching, erythema, hair loss (including eyelash and eyebrow depilation)Psoriasiform eruption, Erythema multiforme
Injection siteSwelling, hemorrhagic spots, burning sensation, or pain at the injection siteTwitching or infection at the injection site, pain and hypertonia of neighboring muscles
BloodDecreased white blood cellsThombocytopneia
Gastro intestineNausea, diarrhea, dry mouthDysphagia, anorexia, vomiting, abdominal pain
Psychiatric, neurologicalDizziness, fainting, sensory abnormalityNerve root disorders, numbness
OthersFacial pain, fever, CK level elevation(blood test), common cold-like symptomsWeakness, fatigue, tinnitus, hearing loss, sweating, denervation atrophy/muscle atrophy, myalgia, abnormal liver function tests

如何預約

肉毒桿菌注射治療的預約只能通過電話進行,因此請致電各診所。

預約掛號/詢問相關資訊

如果您是複診的諮詢,請在聯絡時告知我們您的“病歷號碼”。
●高円寺分院 TEL 03-5913-7435
東京都杉並区高円寺南4-6-7 アンフィニビル4階
週一至週六 10:30-13:30/15:30-18:30
休診日:週日 / 國定假日
●麹町分院  TEL 03-6261-7433
東京都千代田区麹町3-7-4 秩父屋ビルB1階
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週六・週日 10:00-13:00/15:00-18:00
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