Weight Loss Treatment

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Medical weight loss treatment at HADA NO CLINIC

At our clinic, we offer weight loss treatments using medications such as Mounjaro, Ozempic, Rybelsus, Lusefi, and Metformin, all under the supervision of a doctor and with regular check-ups.

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MedicationEffectDosageFeatures
MounjaroWeekly injectionTargets GIP/GLP-1 receptors to suppress appetite and increase energy expenditure
OzempicWeekly injectionTargets GLP-1 receptors to suppress appetite and increase energy expenditure
RybelsusOral, once daily
LusefiOral, once dailyInhibits glucose reabsorption in the kidneys, promoting glucose excretion through urine
MetforminOral, twice dailyInhibits glucose production in the liver and reduces glucose absorption in the digestive tract
Promotes GLP-1 secretion from the intestines to suppress appetite

Mounjaro (Tirzepatide)

Mounjaro (Tirzepatide) Injection

Mounjaro (Tirzepatide) is a once-weekly injection that helps suppress appetite and increase energy expenditure, aiding in weight loss. It works on both GLP-1 and GIP receptors, offering potentially greater weight loss effects compared to medications that target only the GLP-1 receptor.

While Mounjaro is approved as a treatment for diabetes, it has not yet been approved as a weight loss medication in Japan, meaning it is not covered by the Pharmaceutical Side Effect Relief System.

Mounjaro Prices (incl. tax)

DrugPrice / pen
(1 week)
Price / 4 pens
(4 weeks)
Mounjaro
2.5mg
¥5,500¥22,000
Mounjaro
5mg
¥9,900¥39,600
Mounjaro
7.5mg
¥14,300¥57,200
Mounjaro
10mg
¥18,700¥74,800
Mounjaro
12.5mg
¥23,100¥92,400
Mounjaro
15mg
¥26,400¥105,600
ItemPrice
Alcohol swabs (20 pieces)¥165
Anti-nausea medication (10-day supply)¥660
  • A consultation is required for a prescription (¥3,850 for the first visit / ¥1,650 for follow-up visits). Additionally, a blood test (¥3,982) is needed at the initial visit and every three months to monitor for side effects.
  • After use, the needle retracts automatically into the pen for safety. Dispose of the pen in a sturdy container (like a milk carton), seal it with tape, and discard it as burnable trash. If you wish to dispose of items at our clinic, a medical waste fee of ¥440 will be charged.

Dosage and Administration

How to use Mounjaro

Storage:

Store in the refrigerator (2–8°C) and avoid freezing. It can also be stored at room temperature (below 30°C) for up to 3 weeks.

Injection Method:

Inject subcutaneously (into the fat) in the abdomen or thigh once a week, on the same day each week. It can be taken regardless of meals. Do not inject into muscles or veins. Follow the “Instructions for Use” provided during your consultation to use it correctly.

Dosage Schedule:
PeriodDosage
Weeks 1–42.5 mg / week
Weeks 5–85 mg / week
Weeks 9–127.5mg / week
Weeks 13–1610mg / week
Weeks 17–2012.5mg / week
Week 21+15mg / week

Since nausea and discomfort may occur initially, start with 2.5 mg once a week and gradually increase the dose every 4 weeks according to the table, up to a maximum of 15 mg.

  • If the effect is strong or side effects persist, maintain the current dosage without increasing it.

Who Should Not Receive Treatment

You may not be eligible for weight loss treatment if you meet any of the following criteria:

A. All Drugs (Mounjaro / Ozempic / Rybelsus / Lusefi / Metformin)

  1. Pregnant or breastfeeding women
  2. People with diabetes (consult at an insurance-covered facility)
  3. Those with severe kidney or liver issues
  4. Those allergic to similar drugs
  5. Those at risk of hypoglycemia due to extreme exercise, excessive alcohol intake, pituitary/adrenal insufficiency
  6. Those who are underweight (BMI <18.5), have low body fat (<15% men, <20% women), or have eating disorders

In addition to the criteria in section A, you may not be eligible for treatment if:

Mounjaro / Ozempic / Rybelsus
  1. You meet any of the criteria in “A”
  2. You have severe gastrointestinal issues or a history of pancreatitis
  3. You have depression or suicidal tendencies
  4. You have thyroid issues or a family history of medullary thyroid cancer or MEN2

Side Effects

Mounjaro / Ozempic / Rybelsus
1. Gastrointestinal symptoms

Nausea, vomiting, diarrhea, constipation, abdominal discomfort, bloating. Usually temporary and improves with continued use.

2. Injection site reactions (excl. Rybelsus)

Redness, swelling, lumps. Usually temporary. Rotate injection sites.

3. Kidney issues

Dehydration from diarrhea/vomiting may cause kidney problems. Stay hydrated.

4. Increased heart rate

If sustained, stop the medication and consult a doctor.

5. Hypoglycemia

Symptoms include cold sweats, shaking, palpitations, hunger, headaches, drowsiness, seizures. Take 20g of sugar or 200ml juice and rest. Avoid driving or using machinery until symptoms pass.

6. Pancreatitis, gallstones, cholecystitis, cholangitis, jaundice

Rare but seek immediate medical attention for severe abdominal pain, back pain, vomiting, or fever. Rapid weight loss increases the risk of gallstones; keep weight loss under 5% per month.

7. Anaphylaxis, angioedema

Rare but seek emergency help for itching, hives, facial/throat swelling, difficulty breathing, dizziness.

8. Thyroid C-cell tumors (medullary thyroid cancer)

Cases in rats/mice, but human relevance is unclear. Report any neck swelling or lumps. Regular calcitonin blood tests will be conducted.

Pregnancy, Breastfeeding, and Fertility planning

These drugs are not for use during pregnancy or breastfeeding. Discontinue Mounjaro, Ozempic, or Rybelsus 2 months before trying to conceive, and Lusefi or Metformin 1 month before trying to conceive. No reported effects on male fertility.

Drug Interactions

Mounjaro / Ozempic / Rybelsus (Caution)
Oral ContraceptivesMay reduce the effectiveness of birth control pills.
WarfarinMay increase or decrease its effects.
Other Diabetes MedicationsHigher risk of hypoglycemia.

Alcohol Interaction

Moderate drinking is generally safe, but avoid heavy drinking as it can cause hypoglycemia.
【Recommended Limit】Up to 500ml of beer, 1 cup of sake, or 200ml of wine per day.

Interactions Between Diet Medications (Diabetes Drugs)

GLP-1 receptor agonists (Mounjaro, Ozempic, Rybelsus), SGLT2 inhibitors (Lusefi), and Metformin have a low risk of hypoglycemia alone but increase the risk when combined. Follow your doctor’s instructions and get regular check-ups and tests. If you are prescribed diet or diabetes drugs from other clinics, inform your doctor.

References & Website List
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  2. Gabery S, Salinas CG, Paulsen SJ, Ahnfelt-Rønne J, Alanentalo T, Baquero AF, Buckley ST, Farkas E, Fekete C, Frederiksen KS, Helms HCC, Jeppesen JF, John LM, Pyke C, Nøhr J, Lu TT, Polex-Wolf J, Prevot V, Raun K, Simonsen L, Sun G, Szilvásy-Szabó A, Willenbrock H, Secher A, Knudsen LB, Hogendorf WFJ. Semaglutide lowers body weight in rodents via distributed neural pathways. JCI Insight. 2020 Mar 26;5(6):e133429. doi: 10.1172/jci.insight.133429. PMID: 32213703; PMCID: PMC7213778.
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  17. Davies M, Pieber TR, Hartoft-Nielsen ML, Hansen OKH, Jabbour S, Rosenstock J. Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial. JAMA. 2017 Oct 17;318(15):1460-1470. doi: 10.1001/jama.2017.14752. PMID: 29049653; PMCID: PMC5817971.
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